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KMID : 1035520130010010009
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Brain Tumor Research and Treatment : BTRT
2013 Volume.1 No. 1 p.9 ~ p.15
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Molecular Culprits Generating Brain Tumor Stem Cells
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Oh Se-Yeong
Kim Hyung-Gee
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Abstract
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Despite current advances in multimodality therapies, such as surgery, radiotherapy, and chemotherapy, the outcome for patients with high-grade glioma remains fatal. Understanding how glioma cells resist various therapies may provide opportunities for developing new therapies. Accumulating evidence suggests that the main obstacle for successfully treating high-grade glioma is the existence of brain tumor stem cells (BTSCs), which share a number of cellular properties with adult stem cells, such as self-renewal and multipotent differentiation capabilities. Owing to their resistance to standard therapy coupled with their infiltrative nature, BTSCs are a primary cause of tumor recurrence post-therapy. Therefore, BTSCs are thought to be the main glioma cells representing a novel therapeutic target and should be eliminated to obtain successful treatment outcomes.
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KEYWORD
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High-grade glioma, Brain tumor stem cell, Cancer stem cell niche, Brain tumor stem cell reprogramming, Reprogramming factors
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